2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  1

Year :  2012

Pages :   27-33

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Development and In Vitro Evaluation of Mucoadhesive Buccal Tablets of Timolol Maleate



Address:   1Anuradha College of Pharmacy, Chikhli, Maharashtra, India. (443201) 2 Luqman College of Pharmacy, Gulbarga, India. (585102) 3S.N. Institute of Pharmacy, Pusad, Maharashtra, India. (445204)
DOI No: Not Available

ABSTRACT:
The present investigation is concerned with formulation and evaluation of mucoadhesive buccal tablets containing antihypertensive drug i.e. timolol maleate to circumvent the first pass effect and to improve its bioavailability with reduction in dosing frequency and also dose related side effects. The tablets were prepared by direct compression method. The mucoadhesive polymers used in formulation were chitosan, HPMC K4M and HPMC K15M. Tablets were tested for hardness, thickness, weight variation, friability, drug content, swelling, surface pH, bioadhesive strength and in vitro drug release properties. All tablets were acceptable with regard to hardness, thickness, weight variation and friability. The pH of all batches was in acceptable range of 5.6 to 6.6. Batch F10 showed maximum 101.22 % drug content and batch F1 showed maximum swelling index of 59.23 % after 6 hr. Batch F4 showed highest bioadhesive strength of 31.11gm and maximum drug release of 94.52 % in 10 hr. The best mucoadhesive performance and in vitro drug release profile were exhibited by batch F4 and hence it was optimized.
KEYWORDS:
Buccal drug delivery, Surface pH, Swelling index, Timolol Maleate, Bioadhesive strength, In vitro drug release.
Cite:
Aijaz A. Sheikh, Fauziya Firdos, K.R.Biyani, Izhar Shaikh, Mohd. Shahzad. Development and In Vitro Evaluation of Mucoadhesive Buccal Tablets of Timolol Maleate. Research J. Pharm. and Tech. 5(1): Jan. 2012; Page 27-33.
[View HTML]      [View PDF]



Visitor's No. :   640352