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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  1

Year :  2012

Pages :   129-132

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Solubility Enhancement, Physicochemical Characterization and In Vivo Evaluation of the Anti-Inflammatory Activity of Sulfasalazine in Complex with Beta-Cyclodextrin



Address:   A. Kaura1*, Lalit Sharma2 and V. J. Dhar3
1University Institute of Pharmacy, Baba Farid University of Health Sciences, Faridkot.
2Dept. of Applied Chemistry, S.B.S. College of Engineering and Technology, Ferozepur.
3Swift School of Pharmacy, Ghaggar Sarai, Rajpura.
Corresponding author
DOI No: Not Available

ABSTRACT:
A complex with Beta-cyclodextrin was prepared to increase its solubility characteristics. The drug formulations were characterized in the solid state by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). By these physical determinations, drug–polymer interactions were found. Both the solubility and the dissolution rate of the drug in these formulations were increased. Drug contents were determined by UV spectrophotometry at a Lambda max of 359 nm. The phase solubility behavior of sulfasalazine in various concentrations of Beta-CD, in distilled water was obtained at 37 ± 2 °C. The dissolution of sulfasalazine is increased with increasing amounts of the hydrophilic carriers. The complexes of sulfasalazine with Beta-CD were prepared at 1:1, 1:3, 1:5 and 1:7 drug/carrier ratios. The FTIR spectroscopic studies show thestability of sulfasalazine and the absence of well-defined drug–polymer interaction. The anti-inflammatory activity of sulfasalazine Beta-CD complex was evaluated against Carrageenan-induced rat paw oedema and Formaldehyde-induced rat hind paw edema. The Sulfasalazine Beta-CD (1:7) complex exhibited a higher anti-inflammatory activity than the free drug.
KEYWORDS:
Sulfasalazine; Fourier transform infrared spectroscopy; Differential scanning Calorimetry; Anti-inflammatory activity.
Cite:
Asija Rajesh, Asija Sangeeta, Lamba H. S., Bhandari Anil, Kataria Sandeep. Solubility Enhancement, Physicochemical Characterization and In Vivo Evaluation of the Anti-Inflammatory Activity of Sulfasalazine in Complex withBeta-Cyclodextrin. Research J. Pharm. and Tech. 5(1): Jan. 2012; Page 129-132.
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