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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  1

Year :  2012

Pages :   8-13

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Nanoparticle Drug Delivery to Brain – A Review



Address:   Svapnil Sanghavi1*, Misam Polara1, Dipil Patel1, Ruchita Shah2, Jayvadan Patel1 and Manish Patel1
1Nootan Pharmacy College, Visnagar, India, 384315
2 Bhagwan Mahavir College of Biotechnology, Surat, India.
Corresponding author
DOI No: Not Available

ABSTRACT:
The brain is the most delicate and most protected organ of the body. Many pharmaceutical approaches are rendered ineffective in delivering the drug to the brain. The methods that can enhance drug delivery to brain are, therefore of great interest. The nanoparticles are emerged as effective means of delivering the drug to the brain. The present review details the problems in crossing blood brain barrier, the possible mechanisms to cross the BBB, examples of nanoparticles targeted to brain and the methods to prepare them and their characterization. Though less information is available on toxicity, the nanoparticle approach for drug delivery to brain may prove to be very useful in treatment of brain tumour, epilepsy, cerebrovascular diseases and neurodegenerative disorders.
KEYWORDS:
Nanoparticles, brain targeting, Blood brain barrier, Solid lipid nanoparticles.
Cite:
Svapnil Sanghavi, Misam Polara, Dipil Patel, Ruchita Shah, Jayvadan Patel, Manish Patel. Nanoparticle Drug Delivery to Brain – A Review. Research J. Pharm. and Tech. 5(1): Jan. 2012; Page 8-13.
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