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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  1

Year :  2012

Pages :   92-94

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Study of Fluorimetric Properties of Lisinopril Derivatives



Address:   C.M. Jamkhandi*1, J.I. Disouza1 and Chandrashekar Javali2
1Tatyasaheb Kore College of Pharmacy Warananagar, Dist: Kolhapur 416113, Maharashtra, India.
2Government College of Pharmacy, Bangalore 560027, Karnataka State
Corresponding author
DOI No: Not Available

ABSTRACT:
Lisinopril is antihypertensive drug acts by Inhibition of Ace enzyme. Lisinopril derivatives synthesized by coupling or condensation reactions with fluorophores or reagents which produce fluorescent compounds. The fluorescent derivatives of Lisinopril are confirmed by the spectral data like IR, NMR, physical properties such as MP, Rf Value, solubility, and chemical properties. The intensity of fluorescence is higher for Ia, IIa, IIIa, IVa and low for Va, VIa and the derivatives VIIa show no fluorescent properties. The derivatives show different fluorescent property depending upon the reagents coupled. The synthesized products are measured for their fluorescent properties which can be used for identification and estimation of drug.
KEYWORDS:
Synthesis, Florescent compound, Lisinopril, Flourophore.
Cite:
C.M. Jamkhandi, J.I. Disouza, Chandrashekar Javali. Synthesis and Study of Fluorimetric Properties of Lisinopril Derivatives. Research J. Pharm. and Tech. 5(1): Jan. 2012; Page 92-94.
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