Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  9

Year :  2011

Pages :   1413-1417

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Microwave Assisted Rapid and Efficient Synthesis and Screening of Halogenated Anilin-yl-Substituted Thiazolidin-4-One Derivatives for Antimicrobial Activities.



Address:   Basavaraj M. Dinnimath*1, Shashank N.S.1, S.M. Hipparagi1 and Y. Munishama Gowda2
1Dept. of Pharmaceutical Chemistry, KLEU’S College of Pharmacy, Belgaum, Karnataka
2Kemwell Industries Pvt. Ltd., Bangalore, Karnataka.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
3-chloro-4-fluoro phenyl hydrazine was synthesized from 3-chloro 4-fluoro aniline in the presence of hydrazine hydrate. Compound upon treatment with substituted aromatic aldehydes yielded some Schiff’s bases(2,2’-disubstituted-1(3-chloro-4-fluoro)phenyl hydrazones)which upon treatment with mercapto acetic acid afforded some disubstituted thiazolidin-4-ones. These thiazolidin-4-ones were treated with some substituted aromatic aldehydes to arrive at 5-arylidene derivatives of substituted thiazolidin-4-ones. The compounds were structurally confirmed by IR, 1H NMR and Mass spectral data. The synthesized compounds were screened for their antibacterial, antifungal and antitubercular activities.
KEYWORDS:
: Microwave, Schiff’s bases, Thiazolidin-4-ones, Phenyl hydrazones, arylidenes.
Cite:
Basavaraj M. Dinnimath, Shashank N.S., S.M. Hipparagi, Y. Munishama Gowda. Microwave Assisted Rapid and Efficient Synthesis and Screening of Halogenated Anilin-yl-Substituted Thiazolidin-4-One Derivatives for Antimicrobial Activities. Research J. Pharm. and Tech. 4(9): Sept. 2011; Page 1413-1417.
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