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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  9

Year :  2011

Pages :   1400-1403

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Design, Synthesis and Study of Pharmacological and Biological Evaluation of some novel 1-2-4 Triazolo containing Thiosemicarbazide Derivatives



Address:   Sidram A. Nevade*, Sachin G. Lokapure and N.V. Kalyane
Dept. Of Pharmaceutical Chemistry, BLDE’s College of Pharmacy, Bijapur, Karnataka.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Prompted by the observed biological activities of the some thiosemicarbazide triazolo derivatives in continuation of our ongoing studies on novel biologically and pharmacologically active molecules. We have designed and synthesized some new- (3E)-N-(4-amino-5-sulfanyl-4, 5-dihydro-3H-1, 2, 4-triazol-3-yl)-3-(4-methylbenzylidene) triazane-1-carboxamide derivatives as potential antimicrobial, anti-inflammatory and analgesic agents. Some of the compound exhibits the appreciable activity. The synthesized compound R8, R9 and R10 exhibit the appreciable activity, while R1, R2, R5 exhibit the moderate inhibition of the microbial growth. The tested compound shows the result which comparable to the standard gives less value. The R9 and R10 compounds attached the electron windrowing group, this compound exhibit the satisfying activity. The compound R5 and R10 posses the good anti-inflammatory activity, the tested compound result compared with the standard drug which is mentioned in the procedure, while all compound having the moderate analgesic activity.
KEYWORDS:
Minimum inhibitory concentration, Dimethyl formaldehyde, anti-microbial activity, anti-inflammatory activity, Thin layer chromatography and Dimethyl sulfoxide.
Cite:
Sidram A. Nevade, Sachin G. Lokapure, N.V. Kalyane. Design, Synthesis and Study of Pharmacological and Biological Evaluation of some novel 1-2-4 Triazolo containing Thiosemicarbazide Derivatives. Research J. Pharm. and Tech. 4(9): Sept. 2011; Page 1400-1403.
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