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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  9

Year :  2011

Pages :   1363-1366

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Comparative Spectrophotometric Analysis of Simultaneous Estimation of Esomeprazole and Domperidone in Tablet Dosage Form



Address:   Suvarna A. Barse, Seema A. Gosavi and Veena S. Kasture*
Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Dist: Ahmednagar, (M. S.), India,
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Three simple, accurate and economical methods have been developed for the estimation of esomeprazole and domperidone in tablet dosage form. First method is based on the simultaneous equations, wavelengths selected for analysis were 301.0 nm (?max of esomeprazole) and 287.5 nm (?max of domperidone), respectively, in methanol. Second method is Q-analysis method, based on absorbance ratio at two selected wavelengths 291.0 nm (iso-absorptive point) and 301 nm (?max of esomeprazole). Third method is first order derivative spectroscopy using 301.5 nm (zero cross for esomeprazole) and 286.5 nm (zero cross for domperidone). The linearity was obtained in the concentration range of 5-30 µg/ml and 4-20 µg/ml for esomeprazole and domperidone, respectively. The results of the analysis have been validated statistically and by recovery studies.
KEYWORDS:
UV, Tablet dosage form, Esomeprazole, Domperidone.
Cite:
Suvarna A. Barse, Seema A. Gosavi, Veena S. Kasture. Comparative Spectrophotometric Analysis of Simultaneous Estimation of Esomeprazole and Domperidone in Tablet Dosage Form. Research J. Pharm. and Tech. 4(9): Sept. 2011; Page 1363-1366.
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