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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  9

Year :  2011

Pages :   1480-1482

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Validation of an RP-HPLC Method for the Estimation of Bupropion Hydrochloride



Address:   Bhushan Pingale and Ravi Tiwari*
SVKM’s NMIMS University, School of Pharmacy and Technology Management, Shirpur, Dist: Dhule,(MS)-425 405.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A rapid, simple and accurate RP-HPLC method was developed for the estimation of bupropion hydrochloride, using C18 column 250 x 4.6 mm i.d, 5 µm particle size in gradient mode, with mobile phase comprising of phosphate buffer (pH 4.0) and methanol. The flow rate was 1 mL min-1 and the detection wavelength was 252 nm. The retention time for bupropion hydrochloride was found to be 11.52 min. The proposed method was validated as per ICH (Q2R1) guideline with respect to the parameters viz., linearity, precision, accuracy, robustness, limit of detection and limit of quantification.
KEYWORDS:
Bupropion Hydrochloride, RP-HPLC, Gradient.
Cite:
Bhushan Pingale, Ravi Tiwari. Development and Validation of an RP-HPLC Method for the Estimation of Bupropion Hydrochloride. Research J. Pharm. and Tech. 4(9): Sept.2011; Page 1480-1482.
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