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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  9

Year :  2011

Pages :   1471-1474

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Validation of RP-HPLC Method for Simultaneous Estimation of Cetirizine Hydrochloride and Phenylpropanolamine Hydrochloride in Tablet Dosage Form.



Address:   P.S. Dhongle1 , S.J.Sahare2, S.S. Dhongle3, A.S.Mundhey1 and S.P.Wate1
1Sharad Pawar College of Pharmacy, Nagpur- 441110.
2JL.Chaturvedi College of Pharmacy, Nagpur.
3Hislop College, Nagpur.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A Simple, rapid, accurate and precise reversed phase high performance liquid chromatography method has been developed and validated for simultaneous estimation of Cetirizine hydrochloride and Phenylpropanolamine hydrochloride in tablet dosage form. The chromatography system used a reversed phase C18 column with UV-VIS detection at 254nm. Mobile phase consisted of water: methanol: triethylamine (20:80:0.5v/v/v) pH 3.5 adjusted with orthophosphoric acid at flow rate 1mL/min. The calibration curve was linear in concentration range of 5-40 µg/mL for Cetirizine hydrochloride and 40-100µg/mL for Phenylpropanolamine hydrochloride.
KEYWORDS:
RP-HPLC, Cetirizine hydrochloride, Phenylpropanolamine hydrochloride, orthophosphoric acid.
Cite:
P.S. Dhongle, S.J.Sahare, S.S. Dhongle, A.S.Mundhey, S.P.Wate. Development and Validation of RP-HPLC Method for Simultaneous Estimation of Cetirizine Hydrochloride and Phenylpropanolamine Hydrochloride in Tablet Dosage Form. Research J. Pharm. and Tech. 4(9): Sept. 2011; Page 1471-1474.
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