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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  9

Year :  2011

Pages :   1394-1399

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Diclofenac gel



Address:   Priya P. Munshi*, D.S. Mohale, R. Akkalwar and A.V. Chandewar
Department of Quality assurance, P. Wadhwani College of Pharmacy, Yavatmal - 445001.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
It is phynyl acitic acid derivative developed as anti-inflammatory agent. It has analgesic anti-inflammatory antipyretic like actions like other NSAIDS. . It is recommended in long term treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It is also useful acute mescuskelatal disorder post operative pain and dysmenorrhoea Diclofenac sodium gel were developed in seven different formulations (F1 to F7) by employing different grades of polymers such as Hpmck4m and Crbopol940. There the various Diclofenac gels are available in market.but the propose gel is formulated with two key ingredients oleoresin, and l linseed oil contribute to anti-inflammatory effect. The formulations were evaluated for various physical parameters, ph spredibility , drug relese excrutability studies drug released mechanisms.B7formulation showed maximum drug releaseof 8 hours and maximum drug. Finally the gel formulations found to be economical and may overcome the draw backs associated with the drug during its absorption.
KEYWORDS:
Diclofenac sodium, Topical gel, analgesic, antiinflammatory,
Cite:
Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar. Formulation and Evaluation of Diclofenac gel. Research J. Pharm. and Tech. 4(9): Sept. 2011; Page 1394-1399.
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