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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  9

Year :  2011

Pages :   1468-1470

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Validation of UV Spectrophotometric Method for the Estimation of Strontium Ranelate in Sachet Formulation



Address:   *K. Mythili, S. Gayatri, E. Mukesh Kumar, T. Adi Reddy, K. Chitra and C. Uma Maheswara Reddy
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A new simple and reproducible UV spectrophotometric method for the estimation of strontium ranelate in bulk and sachet formulation has been developed. Strontium ranelate is used to treat osteoporosis in women who have passed the menopause. Standard solution of strontium ranelate in monobasic potassium phosphate buffer (pH 3) showed maximum absorbance at 323 nm. Beer-Lambert’s law obeyed in the concentration range of 2-20 µg / ml with correlation coefficient of 0.9981. The percentage recovery was found to be 103.21 %, which reflect that the method is free from interference of impurities during the estimation of drug in formulation. The developed method was validated with respect to linearity, accuracy, precision and specificity.
KEYWORDS:
UV spectrophotometric method, strontium ranelate, buffer.
Cite:
K. Mythili, S. Gayatri, E. Mukesh Kumar, T. Adi Reddy, K. Chitra, C. Uma Maheswara Reddy. Development and Validation of UV Spectrophotometric Method for the Estimation of Strontium Ranelate in Sachet Formulation. Research J. Pharm. and Tech. 4(9): Sept. 2011; Page 1468-1470.
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