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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  9

Year :  2011

Pages :   1432-1435

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Visible Spectrophotometric Determination of Amlodipine Besylate in Bulk Drug and Tablet Dosage Form



Address:   Lakshmi Aswini G.1, Dhachinamoorthi D.2, Seshagiri Rao J.V.L.N.3, Prasada Rao C.H.2 and Surekha M.L.1
1Dept. of Pharmaceutical Analysis, Vagdevi College of Pharmacy, Gurazala- 522415.
2Dept. of Pharmaceutical Analysis, QIS College of Pharmacy, Ongole -523272.
3Dept. of Pharmaceutical Analysis, University College of Pharmaceutical Sciences, Visakhapatnam -530003.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple visible spectrophotometric method has been developed for the estimation of amlodipine besylate in bulk and tablet dosage form. This method is based on the reaction between amlodipine besylate and potassium hydroxide in presence of dimethyl sulphoxide. The yellow chromogen obtained has absorbance maxima at 456nm. It obeys Beer’s law in the concentration range of 3-30 mcg/ml. This method was validated for precision, accuracy, ruggedness and robustness. Statistical analysis proves that the method is reproducible and selective for the estimation of said drug.
KEYWORDS:
Visible spectrophotometry; Amlodipine besylate; Potassium hydroxide; Dimethyl sulphoxide; Validation.
Cite:
Lakshmi Aswini G., Dhachinamoorthi D., Seshagiri Rao J.V.L.N., Prasada Rao C.H., Surekha M.L Visible Spectrophotometric Determination of Amlodipine Besylate in Bulk Drug and Tablet Dosage Form. Research J. Pharm. and Tech. 4(9): Sept. 2011; Page 1432-1435.
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