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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  8

Year :  2011

Pages :   1207-1211

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Transdermal Delivery of Ciclopirox Olamine via Ethosomal and Liposomal Carrier



Address:   Kundlik Girhepunje1*, Ranju Pal1, Ashutosh Upadhayay1 and Thirumoorthy N.2
1NIMS University, Jaipur (Rajasthan)
2Cherraan’s College of Pharmacy, Coimbatore (Tamilnadu)
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Ciclopirox olamine is an antifungal drug for the treatment of cutaneous candidiasis infections. However its oral administration is associated with number of drawbacks. The goal of the current investigation is to evaluate the transdermal potential of novel vesicular carrier. Ciclopirox olamine loaded ethosomes and liposomes were prepared, optimized and characterized. The ethosomal formulation (E9) showed the significant entrapment (72.81±3.5%) by entrapment study, whereas liposome showed only (32.8±2.5%). The size range for ethosomes was observed (152±11 nm) and liposomes (231±23 nm), which was selected for further transdermal permeation studies. Stability study was performed for 120 days, which revealed low aggregation and growth in vesicular size for ethosomes compared to liposomes. Skin entrapment efficiency assessed by confocal laser scanning microscopy (CLSM) which revealed that ethosomes shows more permeation in the deeper layer of the skin (168 µm) compare to liposomes (100 µm). Vesicle skin interaction study also showed that no interaction between the formulation and rat skin. Our results indicate that the ethosomal formulation may be a promising candidate for transdermal delivery of ciclopirox olamine than liposomes for the treatment of number of dermal infections with better efficiency.
KEYWORDS:
Enhanced drug delivery, ethosomes, candidiasis, confocal laser scanning microscopy, vesicle, liposome.
Cite:
Kundlik Girhepunje, Ranju Pal, Ashutosh Upadhayay, Thirumoorthy N. Transdermal Delivery of Ciclopirox Olamine via Ethosomal and Liposomal Carrier. Research J. Pharm. and Tech. 4(8): Aug. 2011; Page 1207-1211.
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