Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  8

Year :  2011

Pages :   1311-1319

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Biological Evaluation of Some New Benzimidazole Derivatives For their Anticonvulsant and Anti-inflammatory activity



Address:   Sanjeev Sharma1*, P.D. Gokulan1, P.S. Jadon2, Sanjay Singh2 and S.S. Shukla3
1Shri Ram Nath Singh Institute of Pharmaceutical Science and Technology, Sitholi, Gwalior
2 Sun Institute of Pharmaceutical Education and Research, Lahar, Gwalior
3Columbia Institute of Pharmacy, Tekari, Raipur, Chhattisgarh
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Benzimidazole is a heterocyclic aromatic organic compound. In step-1, The O-pheylenediamine (13.5 gm and 0.12mol) was placed in a 250 ml round-bottomed flask and 85 percent formic acid (9.2 gm, 8.4 ml and 0.17 mol.) was added to it. The mixture was heated on a water bath for 100oC for 3 hours. The mixture was cooled, 10 percent sodium hydroxide solution was added slowly, with constant rotation of the flask, until the mixture is just alkaline to litmus. In step-2, the mixture of o-pheylenediamine dihydrochloride (5.43 gm and 0.03 mol.), 20 ml of water, acetic acid (5.4 gm, 5.67ml, and 0.09 mol.) was refluxed for 4 hours. The reaction mixture was cooled and basified with gradual addition of concentrated ammonia solution, the precipitate was filtered, dried and recrystallised from 10 % aqueous ethanol. In step-3, the mixture of O-pheylenediamine dihydrochloride (5.43 gm and 0.03 mol.), 20 ml of water, phenyl acetic acid (12.3 gm, 0.09 mol.) was refluxed for 6 hours. The reaction mixture was cooled and basified with gradual addition of concentrated ammonia solution, the precipitate was filtered, dried and recrystallised from 40% aqueous ethanol.
KEYWORDS:
Synthesis and Biological Evaluation of Some New Benzimidazole Derivatives For their Anticonvulsant and Anti-inflammatory activity.
Cite:
Sanjeev Sharma, P.D. Gokulan, P.S. Jadon, Sanjay Singh, S.S. Shukla. Synthesis and Biological Evaluation of Some New Benzimidazole Derivatives For their Anticonvulsant and Anti-inflammatory activity. Research J. Pharm. and Tech. 4(8): August 2011; Page 1311-1319.
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