List of Refereed Journals published by UGC, New Delhi on 28-03-2017-- AJRC (Sr. No.-1025); AJM (Sr. No.-2497); RJET (Sr. No.-7220); RJPP (Sr. No.- 7232): RJPPD (Sr. No.- 7234); RJPT (Sr. No.-7235) (19-Apr-2017)        | List of Refereed Journals published by UGC, New Delhi on 11-01-2017-- Research Journal of Pharmacy and Technology (Sr. No.-275); Asian Journal of Management (Sr. No.-3986); Asian Journal of Research in Chemistry (Sr. No.-4008); Research Journal of Engineering and Technology (Sr. No.-31787); Research (22-Jan-2017)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  8

Year :  2011

Pages :   1307-1310

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Solubility Enhancement of Aceclofenac by Hot Melt Solid Dispersion Technique



Address:   Shaikh Mohammed Vasim* and Rahul Thube
Allana College of Pharmacy, Azam campus, Pune-01.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Aceclofenac drug is practically water insoluble and it belongs to Biopharmaceutical classification system (class II) and its bioavailability is dissolution dependent. Due to poor aqueous solubility aceclofenac was chosen as a drug candidate to improve its solubility and bioavailability. The method Solid Dispersion (SD) of Aceclofenac was done by Hot Melt technique. In this method the drug and polymer PVP K-30 was heated in a porceline dish at 70ÂșC to form a molten mass which is kept to dry at room temperature and hence crystals are formed.This method helps to enhance solubility and thus increase bioavailability of the aceclofenac drug. The Solid Dispersion of optimized formulation F4 (aceclofenac: PVP K-30) was prepared by direct compression and were characterized by IR, DSC, FTIR, Stability studies and invitro drug release at pH 7.4. Solid Dispersion tablet showed a percentage drug release of 84% in 50min as compared to that of the 67% in 50 min of the marketed conventional formulation. Dissolution of drug increased by the Solid Dispersion and hence solubility was also increased. It is concluded that solubility of the aceclofenac was improved by Solid Dispersion with PVP K-30.
KEYWORDS:
Aceclofenac, Solid Dispersion, PVP K-30, In vitro release.
Cite:
Shaikh Mohammed Vasim, Rahul Thube. Solubility Enhancement of Aceclofenac by Hot Melt Solid Dispersion Technique. Research J. Pharm. and Tech. 4(8): August 2011; Page 1307-1310.
[View HTML]      [View PDF]



Visitor's No. :   174282