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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  8

Year :  2011

Pages :   1297-1302

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Transdermal Permeation Enhancement of Valsartan Using Solid Lipid Nanoparticles



Address:   Madgulkar A.R.*, Bhalekar M.R., Kapse S.B., Paygude B.V. and Reddi S.S.
Department of Pharmaceutics, AISSMS College of Pharmacy, Kennedy Road, Near R.T.O. Pune-411001, Maharashtra, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Valsartan is BCS Class II drug having poor bioavailability and used as an antihypertensive agent. Objective: The objective of the work is to improve the permeation of valsartan by incorporating solid lipid nanoparticles (SLN) of valsartan in the transdermal patch. Material: Valsartan, ethyl cellulose, compritol 888, tween 80, polyvinyl pyrrolidone. Method: Valsartan loaded solid lipid nanoparticles (VAL-SLN) were prepared by pre-emulsion sonication method and spray dried to improve the handling, and stability. Scanning Electron Microscopy (SEM) of optimized formulations was carried out to determine morphology of VAL-SLN. Valsartan loaded solid lipid nanoparticles (VAL-SLN) were incorporated into ethyl cellulose (EC) and polyvinyl pyrrolidone (PVP) matrix patch prepared by solvent evaporation method. This patch was evaluated for thickness, weight variation, folding endurance. Ex-vivo skin permeation on rat skin was studied. Result and Discussion: The VAL-SLN with particle size (248.87 nm) and entrapment 98.23± 1.08 %. was prepared and obtained in spray dried form. FTIR indicated absence of any chemical interaction between valsartan and the lipids. The DSC thermogram showed an endotherm shift in VAL-SLN compared to that of lipid and was different from that of drug, The VAL-SLN formulations showed spherical shape with smooth and non porous surface in SEM. Ex-vivo skin permeation studies on plain valsartan and VAL-SLN containing patches showed flux (17.33±0.7 µg/hrs/cm2) and (42.23±3.1 µg/hrs/cm2) respectively. Conclusion: Result of Ex-vivo study shows that the solid lipid nanoparticles can be successfully used as vehicle for improvement permeation of drug.
KEYWORDS:
valsartan, permeation enhancement, solid lipid nanoparticles, Ex-vivo study.
Cite:
Madgulkar A.R., Bhalekar M.R., Kapse S.B., Paygude B.V., Reddi S.S. Transdermal Permeation Enhancement of Valsartan Using Solid Lipid Nanoparticles. Research J. Pharm. and Tech. 4(8): August 2011; Page 1297-1302.
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