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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  8

Year :  2011

Pages :   1292-1296

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Physicochemical Evaluation of Floating Tablets of Captopril



Address:   Chandra Mohan Sahu*, D.K. Tiwari, S.J. Ingale and A.K. Singhai
1Department of Pharmaceutics, Lakshmi Narain College of Pharmacy, Bhopal (M.P.) India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The present work is aimed to formulate and evaluate floating tablets of Captopril for its physicochemical properties and in-vitro buoyancy studies using an effervescent approach for gastro retentive drug delivery system. Captopril effervescent floating tablets were developed direct compression technique in nine different formulations (F1 to F9) by employing different grades of polymers HPMC K4M, HPMC K15M and HPMC K100M and effervescent agents such as sodium bicarbonate. Formulation F5 containing HPMC K15M showed good Buoyancy lag time of 120. And it remained float for more than 12 hr in the release medium.
KEYWORDS:
Captopril, Gastro retentive drug delivery system, Floating tablet, HPMC, Floating Lag Time.
Cite:
Chandra Mohan Sahu, D.K. Tiwari, S.J. Ingale, A.K. Singhai. Formulation and Physicochemical Evaluation of Floating Tablets of Captopril. Research J. Pharm. and Tech. 4(8): August 2011; Page 1292-1296.
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