List of Refereed Journals published by UGC, New Delhi on 28-03-2017-- AJRC (Sr. No.-1025); AJM (Sr. No.-2497); RJET (Sr. No.-7220); RJPP (Sr. No.- 7232): RJPPD (Sr. No.- 7234); RJPT (Sr. No.-7235) (19-Apr-2017)        | List of Refereed Journals published by UGC, New Delhi on 11-01-2017-- Research Journal of Pharmacy and Technology (Sr. No.-275); Asian Journal of Management (Sr. No.-3986); Asian Journal of Research in Chemistry (Sr. No.-4008); Research Journal of Engineering and Technology (Sr. No.-31787); Research (22-Jan-2017)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  7

Year :  2011

Pages :   1151-1153

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Estimation of Tolperisone Hydrochloride and Etodolac in Combined Dosage Form by UV-Spectrophotometric Methods



Address:   Badmanaban R.*, Patel M.J. and Patel C.N.
Department of Quality Assurance, Shri Sarvajanik Pharmacy College, Mehsana-348001, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Two simple, sensitive, rapid, precise UV spectrophotometric methods have been developed and validated for simultaneous estimation of Tolperisone hydrochloride and Etodolac. Recently this combination was approved for treatment of acute muscle spasm in adults, in tablet dosage form, in ratio of 150mg : 400mg. First method is simultaneous equations method, wavelength selected for estimation of Tolperisone hydrochloride and Etodolac are 256 nm and 273 nm respectively. The second method is first order derivative method based on measurement at zero crossover point of another drug, measurement of Tolperisone hydrochloride and Etodolac were carried out at 246.7 nm and 255.2 nm respectively. The linearity was obtained in the concentration range of 3-10.5 µg/ml and 8-28 µg/ml of TOLP and ETD respectively. The proposed methods are successfully applied for the simultaneous determination of both drugs in commercial tablet preparation. The method was validated with respect to linearity, accuracy and precision as per the International Conference on Harmonization (ICH) guidelines.
KEYWORDS:
Tolperisone hydrochloride, Etodolac, simultaneous equations, first order derivative.
Cite:
Badmanaban R., Patel M.J., Patel C.N. Estimation of Tolperisone Hydrochloride and Etodolac in Combined Dosage Form by UV-Spectrophotometric Methods. Research J. Pharm. and Tech. 4(7): July 2011; Page 1151-1153.
[View HTML]      [View PDF]



Visitor's No. :   199518