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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  6

Year :  2011

Pages :   903-904

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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RP-HPLC Determination of Olmesartan Medoxomil and Amlodipine Besylate in tablets



Address:   J. Priyadharisini, D. Saraswathi, Ajitha Aruna, A. Jerad Suresh*
Department of Pharmaceutical chemistry, Madras Medical College, Chennai-600003.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for the estimation of Olmesartan Medoxomil and Amlodipine Besylate in bulk and pharmaceutical formulations. The quantification was carried out using RP-C -18 Phenomenex (250x4.6mm) in isocratic mode with mobile phase comprising50mM Ammonium acetate and Acetonitrile (50:50) v/v. The mobile phase was pumped at a rate of 1.0mL/min and detection was carried out at 239nm.The linearity was found to be in the range 25-125µg/mL. The proposed method was statistically evaluated and can be applied for routine quality control analysis of Olmesartan Medoxomil and Amlodipine Besylate .
KEYWORDS:
Olmesartan medoxomil, Amlodipine besylate, HPLC, Tablets
Cite:
J. Priyadharisini, D. Saraswathi, Ajitha Aruna, A. Jerad Suresh. RP-HPLC Determination of Olmesartan Medoxomil and Amlodipine Besylate in tablets. Research J. Pharm. and Tech. 4(6): June 2011; Page 903-904.
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