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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  6

Year :  2011

Pages :   891-902

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Co-Crystals: An Emerging Trend in Pharmaceutical Industry

Address:   Sevukarajan M*, Thanuja Bachala, Riyaz Sodanapalli and Rahul Nair
Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Tirupathi, Andhra Pradesh, India
*Corresponding Author
DOI No: Not Available

Pharmaceutical co-crystals are long known but little studied class of compounds. It is the effective remedy for compounds that have intrinsic barriers to drug delivery, such as low aqueous solubility, slow dissolution in gastrointestinal media, and low permeability. Co-crystals are thought to have more potential and are much more advantageous than salts, solvates and hydrates because the physicochemical properties of the active pharmaceutical ingredients and the bulk material properties can be modified, whilst maintaining the activity of the drug molecule. Cocrystal presents an interesting option in regulatory point of view. As they are new compounds they offer the chances of patentability with minimal toxicity and bioavailability studies. This review discusses about the methods of preparation, characterization and design of co-crystals. Application of co-crystals to modify physicochemical characteristics of active pharmaceutical ingredients is also discussed with suitable case studies. Co-crystals also present an interesting option with regard to intellectual property rights.
Pharmaceutical co-crystals, physicochemical properties, Regulatory aspect.
Sevukarajan M, Thanuja Bachala, Riyaz Sodanapalli, Rahul Nair. Co-Crystals: An Emerging Trend in Pharmaceutical Industry. Research J. Pharm. and Tech. 4(6): June 2011; Page 891-902.
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