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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  6

Year :  2011

Pages :   972-975

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Biological Activities of Some Novel Heterocyclic Compounds Containing Thiazolidinone Derivatives



Address:   Puttaraj C., Chetan M. Bhalgat, Sandeep K. Chitale and B. Ramesh*
Department of Pharmaceutical Chemistry, S.A.C. College of Pharmacy, B.G.Nagara- 571448, Mandya.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Amino group of thiazole moiety have been treated with various aromatic aldehydes gave corresponding Schiff's bases, 3A-G. These Schiff's bases have been reacted with thioglycolic acid, anhydrous zinc chloride and N,N'-dimethyl Formamide as a solvent to get corresponding novel thiazolidinone derivatives, 4A-G. Structures of all the newly synthesized compounds were confirmed by IR, 1H NMR, and mass spectral data. The synthesized compounds were evaluated for their antioxidant activity. Few compounds were found with potent antioxidant activity.
KEYWORDS:
Thiazole, Thiazolidinone, Sciff’s bases, Antioxidant activity.
Cite:
Puttaraj C., Chetan M. Bhalgat, Sandeep K. Chitale, B. Ramesh. Synthesis and Biological Activities of Some Novel Heterocyclic Compounds Containing Thiazolidinone Derivatives. Research J. Pharm. and Tech. 4(6): June 2011; Page 972-975.
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