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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  6

Year :  2011

Pages :   999-1003

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Evaluation of Garcina indica Whole Fruit Extracts For Hypoglycemic Potential in Streptozotocin Induced Hyperglycemic Rats.



Address:   Khatib N. A.1 and Patil P. A.2
1Department of Pharmacology, K. L. E. University’s College of Pharmacy Belgaum, 59010, Karnataka
2Joint director Research foundation, K. L. E. University, Belgaum, 59010, Karnataka.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Garcinia indica (GI) whole fruit extracts i.e. aqueous, methanol and chloroform were evaluated for its hypoglycemic activity in oral glucose tolerance in glucose loaded euglycemic rats and in streptozotocin (STZ) 50mg/kg induced hyperglycemic rats. Acute treatment of aqueous extract (400mg/kg) markedly improved oral glucose tolerance in glucose (3g/kg) loaded euglycemic rats. Treatment of aqueous extract (400mgmg/kg) in STZ induced hyperglycemic rats showed significant (p<0.0001) reduction in the fasting blood glucose levels both in acute and chronic study, indicating its antihyperglycemic activity. Methanol and chloroform extracts treatment do not showed significant hypoglycemic activity. The result of the present study indicates aqueous extract of GI whole fruit posess significant hypoglycemic activity in STZ induced hyperglycemic rats.
KEYWORDS:
Hyperglycemia, Garcinia indica fruit, hypoglycemic activity, Streptozotocin, OGTT.
Cite:
Khatib N. A., Patil P. A. Evaluation of Garcina indica Whole Fruit Extracts For Hypoglycemic Potential in Streptozotocin Induced Hyperglycemic Rats. Research J. Pharm. and Tech. 4(6): June 2011; Page 999-1003.
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