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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  6

Year :  2011

Pages :   997-998

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Validated RP-HPLC Method for the Quantitation of Candesartan in Bulk and Pharmaceutical Dosage Forms.



Address:   Syeda Kulsum1, G. Vidya Sagar2 and M. Padmalatha1
1Department of Pharmaceutical Analysis, Vijaya College of Pharmacy, Munaganoor (V), Hyathnagar (M), Hyderabad, India-501505.
2KSKV Kachchh University, Bhuj, Kutch, Gujarat, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple, specific, accurate, precise and sensitive Reverse Phase High Performance Liquid Chromatographic method has been developed for the quantitation of candesartan in both pure and pharmaceutical dosage forms. An Inertsil ODS-3V C-18, 5 um column having 250 x 4.6 mm internal diameter in isocratic mode with mobile phase containing ortho phosphoric acid: Acetonitrile (20:80v/v) and adjust the pH to 3.2 by using 0.03M potassium hydrogen phosphate buffer. The flow rate was 1.0 ml / min and the effluents were monitored at 210 nm. The retention time was 8.057min. The linearity was in the range of 50-160 g / ml. This method was validated for linearity, precision, limit of detection, limit of quantitation and accuracy. Statistical analysis proves that the method is reproducible and selective for the estimation of the said drug.
KEYWORDS:
RP-HPLC, candesartan, Validation,mobile phase,inertsil column.
Cite:
Syeda Kulsum, G. Vidya Sagar, M. Padmalatha. Validated RP-HPLC Method for the Quantitation of Candesartan in Bulk and Pharmaceutical Dosage Forms. Research J. Pharm. and Tech. 4(6): June 2011; Page 997-998.
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