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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  6

Year :  2011

Pages :   993-996

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Metronidazole Encapsulation within Chitosan Coated Eudragit RL Microsphers for Site Specific Delivery



Address:   R. Sivakumar1*, V. Ganesan1, Markand Viyas2, N.N. Rajendran2 and M. Kommala3
1The Erode College of Pharmacy, Erode – 638112 (TN)
2Swamy Vivekanandha College of Pharmacy, Tiruchengode - 637 205, India.
3Mohamed Sathak A.J. College of Pharmacy, Chennai-600 119
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The purpose of the work was to formulate and evaluate mucoadhesive microspheres containing metronidazole for the potential delivery of the drug to the colon. Microspheres were prepared by emulsion solvent evaporation method and filled into capsules for polymeric coating. These preparations were characterized for micromeritics study, morphology, percentage drug content, encapsulation efficiency, Percent mucoadhesion and in vitro drug release study. All the microspheres were spherical in shape smooth surface with a mean diameter 58.9 µm – 205.1 µm. The release mechanism were anomalous (non-fickian) diffusion mechanism. The prolonged colonic residence time and enhanced metronidazole stability resulting from the mucoadhesion microspheres of metronidazole might make contribution of complete eradication of amoebiasis.
KEYWORDS:
Metronidazole, Colon targeting, Mucoadhesive microspheres, Eudragit RL, Chitosan.
Cite:
R. Sivakumar, V. Ganesan, Markand Viyas, N.N. Rajendran, M. Kommala. Metronidazole Encapsulation within Chitosan Coated Eudragit RL Microsphers for Site Specific Delivery. Research J. Pharm. and Tech. 4(6): June 2011; Page 993-996.
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