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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  6

Year :  2011

Pages :   976-978

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Estimation of Cefixime Trihydrate and Ofloxacin in Combined Dosage Form by UV-Spectrophotometric Methods.



Address:   Patel A.N.*, Patel H.U., Patel C.N. and Jayswal U.P.
Department of Quality Assurance, Shri Sarvajanik Pharmacy College, Mehsana-348001, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Two simple, sensitive, rapid, precise UV spectrophotometric methods have been developed and validated for simultaneous estimation of Cefixime Trihydrate and Ofloxacin. Recently this combination was approved for treatment of typhoid fever and urinary tract infection in adults, which is available in tablet dosage form. First method is simultaneous equations method, wavelength selected for estimation of Cefixime Trihydrate and Ofloxacin are 289 nm and 298 nm respectively. The second method is first order derivative method based on measurement at zero crossover point of another drug, measurement of Cefixime Trihydrate and Ofloxacin were carried out at 297.8 and 288 nm respectively. The linearity was obtained in the concentration range of 3-15 µg/ml of both the drugs. The proposed methods are successfully applied for the simultaneous determination of both drugs in commercial tablet preparation. The method was validated with respect to linearity, accuracy and precision as per the International Conference on Harmonisation (ICH) guidelines.
KEYWORDS:
Cefixime Trihydrate, Ofloxacin, simultaneous equations, first order derivative.
Cite:
Patel A.N., Patel H.U., Patel C.N., Jayswal U.P. Estimation of Cefixime Trihydrate and Ofloxacin in Combined Dosage Form by UV-Spectrophotometric Methods. Research J. Pharm. and Tech. 4(6): June 2011; Page 976-978.
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