List of Refereed Journals published by UGC, New Delhi on 28-03-2017-- AJRC (Sr. No.-1025); AJM (Sr. No.-2497); RJET (Sr. No.-7220); RJPP (Sr. No.- 7232): RJPPD (Sr. No.- 7234); RJPT (Sr. No.-7235) (19-Apr-2017)        | List of Refereed Journals published by UGC, New Delhi on 11-01-2017-- Research Journal of Pharmacy and Technology (Sr. No.-275); Asian Journal of Management (Sr. No.-3986); Asian Journal of Research in Chemistry (Sr. No.-4008); Research Journal of Engineering and Technology (Sr. No.-31787); Research (22-Jan-2017)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  6

Year :  2011

Pages :   962-964

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Simple Extractive Spectrophotometric Determination of Mesalamine by Acid-Dye Complexation Methods in Solid Dosage Form



Address:   Venugopal Darak*, Arvind B. Karadi, Md. Arshad and S. Appal Raju
Department of Pharmaceutical Analysis, HKES’s College of pharmacy, Sedam road, Gulbarga, Karnataka-585105, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Two simple and sensitive ion-pairing spectrophotometric methods have been developed for the assay of Mesalamine in pure form and in pharmaceutical formulations. The developed methods involve formation of colored chloroform extractable ion-pair complexes of the drug with Bromo Cresol Green (BCG) and Bromo Cresol purple (BCP) in acidic medium. The extracted complexes showed absorbance maxima at 429, 413 nm for BCG, BCP, respectively. Beer’s law was obeyed in the concentration ranges 20-100 and 25-125 _g/ml for both the methods. These methods have been successfully applied for the analysis of drug in pharmaceutical formulations. No interference was observed from common pharmaceutical adjuvants. Results of analysis were validated statistically and through recovery studies.
KEYWORDS:
Mesalamine, Spectrophotometry, Bromo Cresol Green (BCG), Bromo Cresol purple (BCP).
Cite:
Venugopal Darak, Arvind B. Karadi, Md. Arshad, S. Appal Raju. Simple Extractive Spectrophotometric Determination of Mesalamine by Acid-Dye Complexation Methods in Solid Dosage Form. Research J. Pharm. and Tech. 4(6): June 2011; Page 962-964.
[View HTML]      [View PDF]



Visitor's No. :   199520