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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  6

Year :  2011

Pages :   949-950

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development of RP-HPLC Method for Estimation Glipizide



Address:   Mousumi Karpillai and Sachin Dhangar*
G.R.Y. Institute of Pharmacy, Borawan, Khargone-451001 Madhya Pradesh, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A reversed phase HPLC method is developed for the determination of glipizide in pharmaceutical dosage form. Chromatography was carried out on an inertsil C18 column using a mixture of methanol and phosphate buffer (pH 3.4) (55:45 v/v) as the mobile phase at a flow rate of 1ml/min. Detection was carried out at 225nm. The retention time of the drug was 7.098min. The method produced linear responses in the concentration range of 15-75 µg/ml of Glipizide. The method was found to be applicable for the determination of the drug in tablets.
KEYWORDS:
Glipizide, Estimation, Tablets, RP-HPLC.
Cite:
Mousumi Karpillai, Sachin Dhangar. Development of RP-HPLC Method for Estimation Glipizide. Research J. Pharm. and Tech. 4(6): June 2011; Page 949-950.
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