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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  5

Year :  2011

Pages :   744-747

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Assay of Naratriptan Hydrochloride in Bulk and Its Pharmaceutical Formulations by Extraction Spectrophotometry



Address:   C. Ramesh1, G. Nagarjuna Reddy2, T.V. Narayana3, K.V.S. Prasada Rao4 and B. Ganaga Rao5
1V.V.Pura Institute of Pharmaceutical Sciences, Bangalore,
2A.M.Reddy Memorial College of Pharmacy, Narasaraopet, Andhra Pradesh,
3Vikas Institute of Pharmaceutical Sciences, Rajahmundry, Andhra Pradesh,
4Rahul Institute of Pharmaceutical Sciences and Research, Chirala, A.P
5College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Four simple and sensitive spectrophotometric methods (A – D) for the assay of naratriptan hydrochloride in pure and dosage forms based on the formation of chloroform soluble ion-associates under specified experimental conditions are described. Four acidic dyes, namely, wool fast Blue (WFB BL, method A), orange II (Tpooo, method B), Naphthalene Blue 12 BR (NB-12BR, method C), and Azocarmine (AG, method D) are utilized. The extracts of the ion-associates exhibit absorption maxima at 580, 480, 630 and 540 nm for methods A, B, C and D, respectively. Beer’s law and the precision and accuracy of the methods are checked by the UV reference.
KEYWORDS:
Assay of Naratriptan Hydrochloride in Bulk and Its Pharmaceutical Formulations by Extraction Spectrophotometry.
Cite:
C. Ramesh, G. Nagarjuna Reddy, T.V. Narayana, K.V.S. Prasada Rao, B. Ganaga Rao. Assay of Naratriptan Hydrochloride in Bulk and Its Pharmaceutical Formulations by Extraction Spectrophotometry. Research J. Pharm. and Tech. 4(5): May 2011; Page 744-747.
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