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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  5

Year :  2011

Pages :   739-743

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Mucoadhesive Microcapsules of Glimepiride



Address:   J. Satyanarayana*, A. Pavan Kumar, V. Sai Kishore and T.E. Gopala Krishna Murthy
Bapatla College of Pharmacy, Bapatla-522101
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The main objective of this present research is to achieve oral controlled release of Glimepiride and to enhance the gastrointestinal resident time, for this purpose mucoadhesive microcapsules were formulated by employing both ionic gelation method and emulsification gelation method by using sodium alginate and HPMC as coating polymers. Formulated microcapsules were properly evaluated and comparision between two methods were focused. In this present research influence of method on rate of drug release and concentration of polymer coat on rate of drug release from the Glimepiride microcapsules were studies. The rate of drug release was found to be decreased by increasing the concentration of the coat polymer. The rate of drug release was found to be less for microcapsules formulated by Emulsification Gelation Method than compared to microcapsules formulated by Ionic Gelation Method.
KEYWORDS:
Glimepiride, HPMC, Sodium alginate, Mucoadhesive Microcapsules, Emulsification Gelation Method, Ionic Gelation method.
Cite:
J. Satyanarayana, A. Pavan Kumar, V. Sai Kishore, T.E. Gopala Krishna Murthy. Formulation and Evaluation of Mucoadhesive Microcapsules of Glimepiride. Research J. Pharm. and Tech. 4(5): May 2011; Page 739-743.
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