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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  5

Year :  2011

Pages :   719-724

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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In vitro Evaluation of Isosorbide Dinitrate Calcium Alginate Controlled Drug Delivery Beads and Its Modified Form Using Different Cross-Linking Agents



Address:   Nina Varghese1*, Preethi Sudheer1, Soosamma John1, Remesh Babu1 and S.V. Manju2
1East Point College of Pharmacy, Bangalore. 2C.M.R. College of Pharmacy, Bangalore.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Isosorbide dinitrate, a vasodilator is the drug incorporated into calcium alginate beads by encapsulation procedure with polymer sodium alginate and cross-linking agents (Gluteraldehyde and Formaldehye). The Formulations were tested for entrapment efficiency and drug release in various buffered medium. The beads containing formaldehyde as the cross-linking agent was found with maximum drug release of 85% in pH 7.5 and all the three formulations had efficient drug release in basic pH. Effect of pH in release of drug from polymer.
KEYWORDS:
Calcium Alginate Beads, Cross Linking Agents, Encapsulation, Isosorbide dinitrate.
Cite:
Nina Varghese, Preethi Sudheer, Soosamma John, Remesh Babu, S.V. Manju. In vitro Evaluation of Isosorbide Dinitrate Calcium Alginate Controlled Drug Delivery Beads and Its Modified Form Using Different Cross-Linking Agents. Research J. Pharm. and Tech. 4(5): May 2011; Page 719-724.
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