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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  5

Year :  2011

Pages :   787-789

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Reversed Phase High Pressure Liquid Chromatography Technique for Determination of Oxolamine Citrate from Pharmaceutical Formulation



Address:   Rele R.V.* and Patil S.P.
D.G. Ruparel College, Matunga, Mumbai - 400 016.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple, rapid and accurate high performance liquid chromatography method is described for determination of oxolamine citrate from active pharmaceutical ingredients. The separation of drug was achieved on kromasil C18 (250 X 4.6 mm) 5ยต column. The mobile phase consisted a mixture of buffer and methanol (60:40 v/v). The buffer was a mixture of 0.05 M potassium dihydrogen phosphate monobasic and triethylamine. The pH of buffer was adjusted to 4.1 by dilute ortho-phosphoric acid. The detection was carried out at wavelength 230 nm. The method was validated for system suitability, linearity, accuracy, precision, robustness, stability of sample solution. The method has been successfully used to analyze oxalamine citrate from pharmaceutical formulation.
KEYWORDS:
Oxolamine citrate, Reversed phase HPLC, Potassium dihydrogen phosphate monobasic, Triethylamine.
Cite:
Rele R.V., Patil S.P. Reversed Phase High Pressure Liquid Chromatography Technique for Determination of Oxolamine Citrate from Pharmaceutical Formulation. Research J. Pharm. and Tech. 4(5): May 2011; Page 787-789.
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