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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  5

Year :  2011

Pages :   771-774

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Hepatoprotective Activity of Butea monosperma bark on Liver Damage Caused by Paracetamol in Rats.



Address:   Pradeep Kumar Samal*, J.S. Dangi, Kedar Pd. Meena, N.R. Beck, Garima Maheshwari and Aswani Patel.
SLT. Institute of Pharmaceutical Sciences. Guru Ghasidas Vishwavidyalaya, Bilaspur ,Chhattisgarh.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The objective of this study was to investigate the hepatoprotective activity of Butea monosperma bark, against paracetamol induced hepatotoxicity. The Bark was dried in shade, powdered and Extracted with ethanol. Preliminary phytochemical analysis show the presence of phenolic compound and flavanoids. The ethanolic extract of Butea monosperma bark (EEBM) showed a significant dose dependent (250 mg and 500 mg/kg p.o. ) protective effect. The degree of protection was measured by using biochemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), total protein (TP), albumin(Alb) and total bilirubin (TB). The effects of EEBM was comparable to that of standard drug, Silymarin (25mg/kg). All the test drugs were administered orally by suspending in 0.5% of Tween 40 suspension.
KEYWORDS:
Butea monosperma, Paracetamol, Silymarin, and Hepatotoxicity.
Cite:
Pradeep Kumar Samal, J.S. Dangi, Kedar Pd. Meena, N.R. Beck, Garima Maheshwari, Aswani Patel. Hepatoprotective Activity of Butea monosperma bark on Liver Damage Caused by Paracetamol in Rats. Research J. Pharm. and Tech. 4(5): May 2011; Page 771-774.
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