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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  5

Year :  2011

Pages :   762-763

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Spectrophotometric Estimation of Nisoldipine in Bul and Tablet Formulation


V. Niraimathi, A. Jerad Suresh, K. Nanjappan, R. Kokila, T. Latha

vnm_anr@yahoo.co.in

Address:   V. Niraimathi*, A. Jerad Suresh, K. Nanjappan, R. Kokila and T. Latha
Department of Pharmaceutical Chemistry, Madras Medical College, Chennai – 600 003. India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Two simple, precise and economical spectrophotometer methods have been developed for the estimation of nisoldipine in bulk and pharmaceutical preparations. Method A is based on the reaction of nisoldipine with DMSO and potassium hydroxide to form dark yellow chromogen followed by measuring the absorbance at 430nm. Method B involves the reaction of nisoldipine with 4 Dimethyl aminobenzaldehyde to give a yellow coloured chromogen having maximum absorbance at 400nm. Beers concentration for the method A was found to be 20 to 80mg/mL and 50-250mg/mL for method B. The results of the analysis were validated statistically and found to be satisfactory.
KEYWORDS:
Nisoldipine (NIS), Visible spectrophotometry.
Cite:
V. Niraimathi, A. Jerad Suresh, K. Nanjappan, R. Kokila, T. Latha. Spectrophotometric Estimation of Nisoldipine in Bul and Tablet Formulation. Research J. Pharm. and Tech. 4(5): May 2011; Page 762-763.
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