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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   558-560

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous Estimation of Rabeprazole Sodium and Itopride Hydrochloride in Capsule Dosage Form by UV Spectrophotometry



Address:   Shaik Harun Rasheed1*, M. Arief1, P. Sandhya Vani1, Silpa Rani Gajavalli1, G. Venkateswarlu1, K. Shahul Hussain2, N. Vinay Kumar3 and Y. Krishna Reddy4
1 BA&KR College of Pharmacy, Doddavarapadu, Ongole, Andhra Pradesh, INDIA.
2Vagdevi College of Pharmacy, Nellore, Andhra Pradesh, INDIA. 3MRR College of Pharmacy, Nandigama, Andhra Pradesh, INDIA 4Sri Vani College of Pharmacy, Vijayawada, Andhra Pradesh, INDIA
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The simple, accurate and precise methods for simultaneous estimation of Rabeprazole sodium and Itopride hydrochloride in capsule dosage form by Spectrophotometric method, the absorbance values at 284nm and 258nm for Rabeprazole sodium and Itopride hydrochloride. Beer-Lambert’s law over the concentration rang for Rabeprazole sodium was 1-5ug/ml and Itopride hydrochloride 7.5-37.5ug/ml, with r values between 0.9994-0.9998.The percentage recovery value was found to be 100%, it indicates there is no interferences of additives with Rabeprazole and Itopride present in capsule dosage form. The method has been validated as per ICH guidelines and %RSD value NLT 2(<2%) was found. The proposed method was successfully applied for estimation of Rabeprazole and Itopride in combined capsules dosages formulation.
KEYWORDS:
Uv- Spectrophotometry, Rabeprazole sodium, Itopride hydrochloride.
Cite:
Shaik Harun Rasheed, M. Arief, P. Sandhya Vani, Silpa Rani Gajavalli, G. Venkateswarlu, K. Shahul Hussain, N. Vinay Kumar, Y. Krishna Reddy. Simultaneous Estimation of Rabeprazole Sodium and Itopride Hydrochloride in Capsule Dosage Form by UV Spectrophotometry. Research J. Pharm. and Tech. 4(4): April 2011; Page 558-560.
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