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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   521-526

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Effect of Lipids and Surfactants on Solid Lipid Nanoparticle Engineering



Address:   Baviskar Anagha 1*, Hiremath Shivanand1, Akul Manoj2 and Pawar Poonam1
1Department of Pharmaceutics, PRES’S College of Pharmacy, Chincholi, Nashik-422101,
Maharashtra, India. 2Research and Development Cell, Glenmark Pharmaceuticals Ltd., Sinnar, Nashik, Maharashtra, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Solid lipid nanoparticles (SLN) have attracted increasing attention during recent years. SLN consist of biodegradable physiological lipids or lipidic substances and stabilizers which are generally recognized as safe (GRAS) or have a regulatory accepted status. In engineering of SLN lipid and surfactant are very important as they influence the particle size and entrapment efficiency. This paper presents an overview about the effect of lipid and surfactant on formulation of SLN. Lipid crystallinity and polymorphism, the two criteria are studied for stability of SLN. Special attention is paid to the relation between drug loading profile and the release in lipid nanoparticle.
KEYWORDS:
Solid lipid nanoparticles, crystallinity, polymorphism, stability, drug loading profile and release from SLN.
Cite:
Baviskar Anagha, Hiremath Shivanand, Akul Manoj, Pawar Poonam. Effect of Lipids and Surfactants on Solid Lipid Nanoparticle Engineering. Research J. Pharm. and Tech. 4(4): April 2011; Page 521-526.
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