Formulation and In Vitro evaluation of Aceclofenac oral floating tablets

S Gopalakrishnan; A Chenthilnathan

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   642-645

ISSN Print :  0974-3618

ISSN Online :  0974-360X

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Formulation and In Vitro evaluation of Aceclofenac oral floating tablets

S Gopalakrishnan, A Chenthilnathan

ala.chenthil@gmail.com

Address:

S. Gopalakrishnan and A. Chenthilnathan*
Department of Pharmaceutical Chemistry, Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu
*Corresponding Author

DOI No: Not Available

ABSTRACT:

The present study was aimed at preparing a Floating drug delivery system for the model drug, Aceclofenac and evaluating the various processing parameters including the buoyancy studies and in vitro drug release studies. Four formulations containing varying proportions of polymers like HPMC K15M and Micro crystalline cellulose and fixed amount of gas generating agents such as Sodium bi carbonate and anhydrous citric acid were prepared. The tablets were prepared by wet granulation technique and the prepared tablets remained buoyant for more than 8 hrs in the release medium. The proportions of the polymers showed significant difference in the release of the drug. All the formulations exhibited diffusion dominant drug release and were found to be stable.

KEYWORDS:

Aceclofenac, Floating drug delivery system, Buoyancy, in vitro drug release.

Cite:

S Gopalakrishnan, A Chenthilnathan. Formulation and In Vitro evaluation of Aceclofenac oral floating tablets. Research J. Pharm. and Tech. 4(4): April 2011; Page 642-645.

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