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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   631-633

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development of First Order Derivative UV –Spectrophotometric Method for the Estimation of Sitagliptin Phosphate



Address:   Pallaw Ghodeswar*, Avnish Jain and Sanjay Jain
Smriti College of Pharmaceutical Education 4/1 Pipliya Kumar, Mayakhedi Road, Dewas Naka, Nipania, Indore (M.P.) – 452010, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple, rapid, sensitive, economic and accurate first order derivative Spectrophotometric method has been developed for the estimation of Sitagliptin Phosphate in bulk and tablets. In distilled water ?max of Sitagliptin Phosphate was found to be 267.4 nm. The same spectra was derivatized using derivative mode into first order derivative at ?N =5, the amplitude of peak was measured at 256.4 nm. In the method linearity was observed in the concentration range of 5-35 µg/ml. the assay results by the proposed method were in good agreement with label claim, the method was validated statistically and recovery studies.
KEYWORDS:
Sitagliptin phosphate, Spectrophotometric method, first order derivative.
Cite:
Pallaw Ghodeswar, Avnish Jain, Sanjay Jain. Development of First Order Derivative UV –Spectrophotometric Method for the Estimation of Sitagliptin Phosphate. Research J. Pharm. and Tech. 4(4): April 2011; Page 631-633.
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