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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   624-628

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Antimicrobial activity of Pyrimidine Derivatives from Amine



Address:   Sanjay Chauhan1*, A. K. Gyananchandran1, Pawan Tiwari1, Sanjeev Sharma2 and S.S. Shukla3
1Pranav Institute of Pharmaceutical Science and Research, Sitholi (Gwalior)
2Shri Ramnath Singh Institute of Pharmaceutical Science and Technology, Sitholi (Gwalior)
3Columbia Institute of Pharmacy, Tekari, Raipur, Chhattisgarh
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Pyrimidine is a heterocyclic aromatic organic compound which containing two nitrogen atoms at positions 1 and 3 of the six-member ring. In step-1, equimolar (0.02 mole) mixtures of Aromatic primary amines were refluxed in 40ml of dry ethanol for 18 hours. In step-2, an equimolar (0.02moles) mixture of Schiff’s base and Thioglycolic acid were refluxed for 18hr in 30ml of dry benzene. Then the excess benzene was distilled off under reduced pressure and the contents were poured over crushed ice and centrifuged. In step-3, Aromatic aldehydes and anhydrous sodium acetate (0.082gm) in 20ml of glacial acetic acid was refluxed for 3hrs. Then the reaction mixture was concentrated, cooled and poured into ice cold water. In step-3 and step-4, Thiourea or ureas were dissolved in ethanol (50ml). To this NaOH dissolved to minimum quantity of water was added. Then the mixture was refluxed for 6hrs and poured into 250ml of cold water. After complete these four steps, we collect the some pyrimidine derivatives compounds and show antibacterial and antimicrobial activity.
KEYWORDS:
Synthesis and Antimicrobial activity of Pyrimidine Derivatives from Amine.
Cite:
Sanjay Chauhan, A. K. Gyananchandran, Pawan Tiwari, Sanjeev Sharma, S .S. Shukla. Synthesis and Antimicrobial activity of Pyrimidine Derivatives from Amine. Research J. Pharm. and Tech. 4(4): April 2011; Page 624-628.
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