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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   592-595

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simple and Sensitive LC-UV Method for Simultaneous Analysis of Lecarnidipine Hydrochloride and Atenolol in Pharmaceutical Formulations



Address:   Devika G.S. 1*, M. Sudhakar1 and J. Venkateshwara Rao2
1Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Maissamaguda, Dullapally, Secunderabad -14 Andrapradesh, India.
2Department of Pharmaceutical Chemistry, Sultan Ul Uloom College of Pharmacy, Road No3, Banjara Hills , Secunderabad- 500034 Andrapradesh, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple, sensitive and inexpensive high performance liquid chromatographic method has been developed for simultaneous determination of Atenolol and Lecarnidipine hydrochloride in pharmaceutical formulations. Chromatographic separation was achieved on a Phenomenex Gemini ODS column with a 75:25 mixture of methanol: water final PH (4.0±0.1); as a mobile phase. Detection was at 274nm.The calibration curve was linear in the concentration range 60-180µg/ml for Atenolol 12-32µg/ml for Lecarnidipine Hydrochloride; the correlation coefficients were 0.9992 and 0.9991, repectively. Total elution time was less than 5 min.
KEYWORDS:
Lecardipine hydrochloride, Atenolol, Simultaneous determination.
Cite:
Devika G.S. , M. Sudhakar, J. Venkateshwara Rao. Simple and Sensitive LC-UV Method for Simultaneous Analysis of Lecarnidipine Hydrochloride and Atenolol in Pharmaceutical Formulations. Research J. Pharm. and Tech. 4(4): April 2011; Page 592-595.
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