2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   578-581

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Allready Registrered
Click to Login

Development and Evaluation of Controlled Release Mucoadhesive Tablet

Address:   V.N Deshmukh* and D.M. Sakarkar
Sudhakarrao Naik Institute of Pharmacy, Pusad, 445204 (MS)
*Corresponding Author
DOI No: Not Available

Mucoadhesive controlled release tablet can improve the effectiveness of a drug by maintaining the drug concentration between the effective and toxic levels, and allowing targeting and localization of a drug at a specific site. Mucoadhesive oral tablets were formulated by using model drug as Captopril and mucoadhesive polymers such as Carbopol 974P and Hydroxy propyl methylcellulose (HPMC K4 M and HPMC K15 M). The polymers were used in different concentrations to provided sustained release of drug over a period of 12 hr. along with mucoadhesion. Drug release from these tablets was diffusion controlled and followed non-Fickian release. Tablets also exhibited good swelling and mucoadhesive strength.
Captopril, Carbopol, HPMC, Mucoadhesive.
V.N Deshmukh, D.M. Sakarkar. Development and Evaluation of Controlled Release Mucoadhesive Tablet. Research J. Pharm. and Tech. 4(4): April 2011; Page 578-581.
[View HTML]      [View PDF]

Visitor's No. :   687533