Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   578-581

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Evaluation of Controlled Release Mucoadhesive Tablet



Address:   V.N Deshmukh* and D.M. Sakarkar
Sudhakarrao Naik Institute of Pharmacy, Pusad, 445204 (MS)
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Mucoadhesive controlled release tablet can improve the effectiveness of a drug by maintaining the drug concentration between the effective and toxic levels, and allowing targeting and localization of a drug at a specific site. Mucoadhesive oral tablets were formulated by using model drug as Captopril and mucoadhesive polymers such as Carbopol 974P and Hydroxy propyl methylcellulose (HPMC K4 M and HPMC K15 M). The polymers were used in different concentrations to provided sustained release of drug over a period of 12 hr. along with mucoadhesion. Drug release from these tablets was diffusion controlled and followed non-Fickian release. Tablets also exhibited good swelling and mucoadhesive strength.
KEYWORDS:
Captopril, Carbopol, HPMC, Mucoadhesive.
Cite:
V.N Deshmukh, D.M. Sakarkar. Development and Evaluation of Controlled Release Mucoadhesive Tablet. Research J. Pharm. and Tech. 4(4): April 2011; Page 578-581.
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