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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  3

Year :  2011

Pages :   389-392

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Derivative and Absorption Factor Spectrophotometric Estimation of Montelukast Sodium and Levocetirizine Dihydrochloride from Pharmaceutical Formulations



Address:   Vishnu P. Choudhari*, Anamika N. Kale, Satish A.Polshettiwar, Abhijit S. Sutar, Dhaval M. Patel and Bhanudas S. Kuchekar
Pharmaceutical Analysis and Quality Assurance Department, MAEER’s Maharashtra Institute of Pharmacy, MIT Campus, Paud Road, Kothrud, Pune, 411038, MS, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Two simple and sensitive spectrophotometric methods are described for the determination of Montelukast sodium and Levocetirizine Dihydrochloride in combined dosage form. First method was first order derivative spectroscopy where montelukast and levocetirizine were determined at ?max 340nm and 331nm, respectively in methanol. The second method was based on the absorption factor in which montelukast and levocetirizine exhibit ?max at 232 nm and 279 nm respectively in methanol. Montelukast has some interference at 232nm, while levocetirizine do not show any absorption at 279 nm. Quantitative estimation of levocetirizine was carried out by subtracting the absorption due to montelukast at 232nm using experimentally calculated absorption factor. Beer’s law was obeyed for montelukast and levocetirizine in the concentration range of 4-12 µg ml-1 and 2-6 µg ml-1 , respectively for both methods. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method.
KEYWORDS:
Montelukast, Levocetirizine, absorption factor, Derivative Spectrophotometry.
Cite:
Vishnu P Choudhari, Anamika N Kale, Satish APolshettiwar, Abhijit S Sutar, Dhaval M Patel, Bhanudas S Kuchekar. Derivative and Absorption Factor Spectrophotometric Estimation of Montelukast Sodium and Levocetirizine Dihydrochloride from Pharmaceutical Formulations. Research J. Pharm. and Tech. 4(3): March 2011; Page 389-392.
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