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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  3

Year :  2011

Pages :   358-388

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Bioadhesive Micro Beads of Ketoprofen for Controlled and Site Specific Delivery

Address:   R. Sivakumar1*, N. Narayanan2 and N.N. Rajendran1 1Swamy Vivekanandha College of Pharmacy, Tiruchengode-637 205.(TN) 2College of Pharmacy, Madras Medical College, Chennai-600 003, India *Corresponding Author
DOI No: Not Available

The objective of this work was to design mucoadhesive oral controlled release drug delivery system for ketoprofen to target the small intestine. Mucoadhesive microbeads containing Ketoprofen were prepared by ionic gelation method using sodium alginate, pectin, and xanthan gum as polymers. The prepared beads were coated with 1% chitosan solution and dried. The dried beads were filled into hard gelatin capsules and coated by a enteric polymer. All microbeads were nearly spherical in shape with rough surface with the mean particle size of 1.6 mm – 1.8 mm. Of the six formulations prepared and evaluated formulas A6 were found satisfactory results. The release followed zero order release with non-Fickian diffusion.
Ketoprofen, ionic gelation, beads, mucoadhesion, small intestine.
R Sivakumar, N Narayanan, NN Rajendran. Bioadhesive Micro Beads of Ketoprofen for Controlled and Site Specific Delivery. Research J. Pharm. and Tech. 4(3) March 2011; Page 385-388.
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