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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  3

Year :  2011

Pages :   75-379

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Evaluation of Schiff’s Bases and Their Azetidinone Derivatives for It’s Antibacterial Activity



Address:   Vijayabaskaran M.*, Senthilraja M., Babu G. and Sajeer P.

Department of Pharmaceutical Chemistry, J.K.K Nataraja College of Pharmacy, P.Box.151, Natarajapuram, Salem Main Road, Komarapalayam, Namakkal District- 638183. Tamilnadu.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A series of Schiff’s bases were prepared by the condensation of various aryl amines with hydroxy benzaldehyde in the presence of ethanol. The synthesized Schiff’s bases were converted to 2-azetidinone derivatives by reacting with triethylamine which is dissolved in dioxane and chloro acetyl chloride. The synthesized compounds were characterized on the basis of their elemental analysis and spectral data. Antimicrobial activities of the synthesized compounds were evaluated. The result reveals that the test compounds E and F exhibit good activity and remaining compounds show moderate anti-bacterial activity when compared to the standard drug Sparfloxacin.
KEYWORDS:
Schiff’s bases; 2-Azetidinone; Antibacterial; Sparfloxacin.
Cite:
Vijabaskaran M, Senthilraja M, Babu G, Sajeer P. Synthesis and Evaluation of Schiff’s Bases and Their Azetidinone Derivatives for It’s Antibacterial Activity. Research J. Pharm. and Tech. 4(3): March 2011; Page 375-379.
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