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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  3

Year :  2011

Pages :   465-471

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Detection of Free Radicals Using GC/MS Trapped By Proxyl Derivatives

Address:   Sai Krishna Putta* and Bala Krishna Talupula
Vijaya Institute of Pharmaceutical Sciences for Women’s, Enikepadu, Vijayawada, Andhra Pradesh, India.
*Corresponding Author
DOI No: Not Available

The free radicals are having much importance in the body and which they lead to cell degradation via different path ways. To avoid the free radical interaction with the cells in the body the spin trapping agents normally nitraso compounds are used to trap them later which they leads to formation of Spin adduct easily excreted by the body. In This current research the methyl and ethyl radicals are trapped by using 3-Carboxy-PROXYL and 3-Carbamoyl-PROXYL and were finally identified by Gas Chromatography Mass Spectrometry. Initially, Fenton chemistry along with the 3-Carboxy-PROXYL and/or 3-Carbamoyl-PROXYL is used for the generation of hydroxyl radicals, and then these are used in the oxidation of di-methyl sulfoxide (DMSO), and ethanol producing methyl and ethyl radicals that were spin trapped and were identified by GC/MS. This research was indirectly used to detect hydroxyl radicals by trapping methyl and ethyl radicals.
Free radicals, Spin-trap, Gas Chromatography Mass Spectrometry.
Sai Krishna Putta, Bala Krishna Talupula. Detection of Free Radicals Using GC/MS Trapped By Proxyl Derivatives. Research J. Pharm. and Tech. 4(3): March 2011; Page 465-471.
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