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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  3

Year :  2011

Pages :   461-464

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous Spectrophotometric Estimation of Aceclofenac and Tizanidine Hydrochloride in Combined Tablet Dosage Form



Address:   Balap Aishwarya R.1*, Khidse Anuja S.1, Prasad Deepshikha V.1, Jadhav Shailaja B.1, Ingale Pramod L.2 and Chaudhari Praveen D.1
1PES’s Modern College of Pharmacy, Yamunanagar, Nigdi, Pune-411 044, 2Marathwada Mitramandal’s College of Pharmacy, Kalewadi, Pune-411 033.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Three simple, precise and economical spectrophotometric methods have been developed for the simultaneous estimation of Aceclofenac (ACF) and Tizanidine Hydrochloride (TZH) in combined tablet dosage form. The first method is simultaneous equation method, second method is based on the determination of Q-value and third method is Area under the Curve method. All methods utilize Methanol: Water (25:75) as solvent. Simultaneous equation method involves the measurement of absorbances at 273.5 nm (?max of ACF) and 227.5 nm (?max of TZH). The absorption ratio (Q-value) was determined at 218.5 nm (Iso-absorptivity point) and 227.5 nm (?max of TZH). For AUC method, wavelength range between 270-275 nm and 225-230 nm were selected for ACF and TZH respectively. Both the drugs obey Beer’s law in the concentration ranges employed for these methods. All three methods were statistically validated and the results of recovery studies were found to be satisfactory. All the methods were found to be simple, rapid, and accurate and can be adopted in routine analysis of drugs in formulations.
KEYWORDS:
Simultaneous equation method, absorption ratio method, AUC method.
Cite:
Balap Aishwarya R , Khidse Anuja S, Prasad Deepshikha V, Jadhav Shailaja B, Ingale Pramod L, Chaudhari Praveen D. Simultaneous Spectrophotometric Estimation of Aceclofenac and Tizanidine Hydrochloride in Combined Tablet Dosage Form. Research J. Pharm. and Tech. 4(3): March 2011; Page 461-464.
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