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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  3

Year :  2011

Pages :   457-460

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Bioavailability Enhancement of Curcumin through Mucoadhesive Drug Delivery System



Address:   Latheeshjlal. L*, Sunil Murala, Vaidya Mehul J., G. Swetha and Phanitejaswini Swapna
Department of Pharmaceutics, Karpagam University, Coimbatore. Tamilnadu
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The main objective of this study was to improve the bioavailability of curcumin through buccal route. Curcumin is practically insoluble in water. After oral administration, most part of the drug was metabolized in liver. Therefore an attempt has been made to improve the bioavailability by using different conc. of sodium lauryl sulphate (0.1, 0.25 0.50 and 1 %) as bioenhancer. Buccal bilayer tablets were prepared by direct compression with different ratio of HPMC.K4M. (1, 2.5, 5 and 7.5%) as bioadhesive polymer and ethyl cellulose (10, 20, 30 and 40%) as backing layer. The formulation were characterized for physicochemical parameter such as weight variation, thickness, hardness, friability, mucoadhesive strength, drug content, swelling studies and in vitro diffusion studies. The best mucoadhesive performance and in vitro drug release profile were exhibited by tablets containing hydroxy propyl methyl cellulose K4M (5%) and sodium lauryl sulphate (0.1%). This product was more comfortable to the user due to absence of erosion, faster hydration rate and less viscosity of surrounding environment. To conclude that the formulated unidirectional, bilayered, buccoadhesive tablet for curcumin using HPMC as mucoadhesive agent is superior to oral conventional tablets, as it has the potential to bypass the first pass metabolism and improve the bioavailability of curcumin.
KEYWORDS:
Curcumin, HPMC, Ethylcellulose, sodium lauryl sulphate.
Cite:
LatheeshjlalL, Sunil Murala, Vaidya Mehul J, G Swetha, Phanitejaswini Swapna. Bioavailability Enhancement of Curcumin through Mucoadhesive Drug Delivery System. Research J. Pharm. and Tech. 4(3): March 2011; Page 457-460.
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