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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  3

Year :  2011

Pages :   450-453

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Validation of New Spectrophotometric Methods for the Determination of Fluvoxamine as Maleate in Pharmaceutical Formulations



Address:   Medikondu Kishore*, A. Koteswarao and M. Janardhan
Department of Chemistry, SVRM College, Nagaram, Guntur (District) Andhra Pradesh, India- 522268
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Two simple extractive spectrophotometric methods are described for the determination of Fluvoxamine as maleate (FXA) in pure form and in pharmaceutical formulations. These methods are based on the formation of ion association complexes of the FXA with 3-(4-(dimethyl amino) phenyl) acryl aldehyde (PDAC) (M1) and Ninhydrin (NH) (M2) in basic buffer of pH 9.8 followed by their extraction in chloroform. The absorbance of the chloroform layer for each method was measured at its appropriate ?max against the reagent blank. These methods have been statistically evaluated and found to be precise and accurate. The procedures described were applied successfully to the determination of the compound in their dosage forms. The results showed that the proposed procedures compared favorably with the reference method and satisfactory sensitivity, accuracy and precision. The optical characteristics such as Beer’s law limits, molar absorptivity and sandell’s sensitivity are reported. Regression analysis using the method of least squares was made to evaluate the slope (b), intercept (a) and correlation coefficient (r) and standard error of estimation (Se) for the drug.
KEYWORDS:
Fluvoxamine maleate, spectrophotometric methods, statistical analysis, recovery studies.
Cite:
Medikondu Kishore, A Koteswarao, M Janardhan. Validation of New Spectrophotometric Methods for the Determination of Fluvoxamine as Maleate in Pharmaceutical Formulations. Research J. Pharm. and Tech. 4(3): March 2011; Page 450-453.
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