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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  3

Year :  2011

Pages :   446-449

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Visible Spectrophotometric Estimation of Tenofovir Disoproxil Fumarate in Pharmaceutical Formulations



Address:   P. Janaki Pathi1*, P. Raveendra Reddy2 and N. Appala Raju3
1Analytical Department, Vishnu Chemicals Limited, Jeedimetla, Hyderabad.
2,2Department of Chemistry, Sri Krishnadevaraya University, Anantapur-515 003
3Department of Pharmaceutical Chemistry, Sultan-Ul-Uloom College of Pharmacy Mount Pleasant,Road # 3, Banjara Hills, Hyderabad-500 034
.*Corresponding Author
DOI No: Not Available

ABSTRACT:
Three simple, accurate, rapid and sensitive methods (A, B and C) have been developed for the estimation of Tenofovir Disoproxil Fumarate in its pharmaceutical dosage form. The Method A is based on the formation of golden yellow colored chromogen, due to ion-association of Tenofovir with Metanil Yellow dye in Chloroform, which exhibits ? max at 425 nm. Method B is based on the formation of reddish brown colored chromogen due to ion-association of Tenofovir with Solochrome Black-T dye in Chloroform, which exhibits ? max at 438 nm. The Method C is based on the formation of blood red colored chromogen with Ferric Chloride and 2,2-Bipyridyl which shows absorption maximum at 523 nm. The absorbance-concentration plot is linear over the range of 10-60 µg/mL for Method A, 10-60 µg/mL for Method B and 20-90 µg/mL for Method C. Results of analysis for all the methods were validated statistically and by recovery studies. The proposed methods are economical and sensitive for the estimation of Tenofovir Disoproxil Fumarate in bulk drug and in its formulations.
KEYWORDS:
UV-Visible Spectrophotometry, Tenofovir Disoproxil Fumarate, Metanil Yellow, Solochrome black-T, 2, 2-Bipyridyl.
Cite:
P Janaki Pathi, P Raveendra Reddy, N Appala Raju. Visible Spectrophotometric Estimation of Tenofovir Disoproxil Fumarate in Pharmaceutical Formulations. Research J. Pharm. and Tech. 4(3): March 2011; Page 446-449.
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