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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   254-258

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Evaluation of Ethanolic Extract of Moringa Oleifera for Wound Healing, Anti-inflammatory and Antioxidant Activities on Rats



Address:   Charde RM1*, Charde MS1, Fulzele SV2, Satturwar PM3, Kasture AV1 and Joshi SB1
1Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Campus, Amrawati Road, Nagpur 440033
2College of Pharmacy, Florida, A&M University, Tallahassee, Florida 32307, USA.
3Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The present study deals with evaluation of continuous heat extracted fraction of Moringa oleifera leaves for antioxidant, wound healing and anti-inflammatory activity in albino wistar rats. The antioxidant activity was carried out by conventional DPPH radical scavenging method, wound healing activity was performed by considering incision, excision, dead space wound model followed by histopathological studies and anti-inflammatory activity was carried out by using carageenan induced rat paw oedema method. The wounds treated with experimental extract shows faster wound closure (24-27 days) and epithelization as compared to wound under untreated group (more than 30 days). The different diluted extract shows antioxidant activity in range of 16.24% to 32.78%. The extract shows significant anti-inflammatory activity as compared to standard reference drug ibuprofen. The result revealed that the anti-inflammatory activity possibly attribute to its free radical scavenging property.
KEYWORDS:
Wound healing, Antioxidant, Anti-inflammatory, Moringa oleifera, Wound model.
Cite:
Charde RM, Charde MS, Fulzele SV, Satturwar PM, Kasture AV, Joshi SB. Evaluation of Ethanolic Extract of Moringa Oleifera for Wound Healing, Anti-inflammatory and Antioxidant Activities on Rats. Research J. Pharm. and Tech. 4(2): February 2011; Page 254-258.
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