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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   252-253

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Spectrophotometric Estimation of Granisetron in Bulk and Tablet Formulation



Address:   S. Angayer Kanchana, Ajithadas Aruna*, V. Niraimathi and A. Jerad Suresh
Department of Pharmaceutical Chemistry, Madras Medical College, Chennai – 600 003. India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Three simple, precise and economical spectrophotometric methods have been developed for the estimation of granisetron in bulk and pharmaceutical preparations. Method A is based on the reaction of granisetron with Ferric chloride and 2, 2’ Bipyridyl to form blood red chromogen and followed by measuring the absorbance at 522nm. Method B is based on the reaction of granisetron with Ferric chloride and Potassium Ferricyanide to form bluish green chromogen and followed by measuring the absorbance at 820nm. Method C involves the determination of granisetron by absorbance ratio method. In this method the ratio of absorbances at any two wavelengths (301nm and 225nm) is constant for all concentrations were determined. The results of the analysis were validated statistically and found to be satisfactory.
KEYWORDS:
Granisetron (GRN), Visible spectrophotometry, Q-Value.
Cite:
S Angayer Kanchana, Ajithadas Aruna, V Niraimathi, A Jerad Suresh. Spectrophotometric Estimation of Granisetron in Bulk and Tablet Formulation. Research J. Pharm. and Tech. 4(2): February 2011; Page 252-253.
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